NUCLEOTIDE-SEQUENCE AND STRUCTURE-ANALYSIS OF CDNAS ENCODING SHORT-CHAIN NEUROTOXINS FROM VENOM GLANDS OF A SEA-SNAKE (AIPYSURUS-LAEVIS)

被引：20

作者：

DUCANCEL, F

GUIGNERYFRELAT, G

BOULAIN, JC

MENEZ, A

机构：

[1] Service de Biochimie, Laboratoire d'Ingénierie des Protéines, Département de Biologie

来源：

TOXICON | 1990年 / 28卷 / 01期

关键词：

D O I：

10.1016/0041-0101(90)90013-W

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

F. Ducancel, G. Guignery-Frelat, J.-C. Boulain and A. Ménez. Nucleotide sequence and structure analysis of cDNAs encoding short-chain neurotoxins from venom glands of a sea snake (Aipysurus laevis). Toxicon 28, 119-123, 1990.-Two cDNAs from the sea snake Aipysurus laevis have been cloned and sequenced. They encode isoforms of short chain neurotoxins. One of them is toxin b, previously isolated from the venom of Aipysurus laevis and sequenced by Maeda and Tamiya (Biochem. J. 153, 79, 1976), whereas the other corresponds to an isoform which was not hitherto described. The two toxin sequences differ from each other by three amino-acid residues. Both cDNA structures were comparable with that previously determined in our laboratory for erabutoxin a from Laticauda semifasciata. © 1989.

引用

页码：119 / 123

页数：5

共 23 条

[1] PURIFICATION OF BIOLOGICALLY-ACTIVE GLOBIN MESSENGER-RNA BY CHROMATOGRAPHY ON OLIGOTHYMIDYLIC-ACID-CELLULOSE [J].