SEQUENCE OF RAT LIPOPROTEIN LIPASE-ENCODING CDNA

被引：37

作者：

BRAULT, D

NOE, L

ETIENNE, J

HAMELIN, J

RAISONNIER, A

SOULI, A

CHUAT, JC

DUGAIL, I

QUIGNARDBOULANGE, A

LAVAU, M

GALIBERT, F

机构：

[1] CHU PITIE SALPETRIERE, F-75013 PARIS, FRANCE

[2] HOP ST LOUIS, CTR HAYEM, CNRS, UPR 41, F-75010 PARIS, FRANCE

[3] INSERUM, U 117, F-75006 PARIS, FRANCE

[4] UNIV PARIS 06, BIOCHIM & BIOL MOLEC LAB, F-75571 PARIS 12, FRANCE

来源：

GENE | 1992年 / 121卷 / 02期

关键词：

MOUSE; HUMAN; BOVINE; GUINEA PIG; CHICKEN; PCR; UNTRANSLATED EXON; A+T-RICH SEQUENCES; CPG ISLANDS;

D O I：

10.1016/0378-1119(92)90127-B

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A rat lipoprotein lipase (LPL)-encoding cDNA (LPL) has been entirely sequenced and compared to the sequences of all the LPL cDNAs reported in other species. As expected, high homology was found between the coding exons. The putative catalytic triad, Ser132 , Asp156 , His241, according to human numbering, is conserved in rat. As is the case in mouse, an Asn444 present in human LPL is also missing. The major divergences between human, mouse and rat LPLs were observed in the untranslated exon 10, where (i) the rat cDNA exhibits a 157-bp insertion and an 81-bp deletion relative to human; (ii) neither the B1 repeat nor the homopurine stretch reported in mouse can be recognized, and (iii) the rat cDNA displays several A+T-rich stretches.

引用

页码：237 / 246

页数：10

共 29 条

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