INHIBITION OF INFLUENZA-VIRUS REPLICATION IN TISSUE-CULTURE BY 2-DEOXY-2,3-DEHYDRO-N-TRIFLUOROACETYLNEURAMINIC ACID (FANA) - MECHANISM OF ACTION

被引：261

作者：

PALESE, P

COMPANS, RW

机构：

[1] CUNY, MT SINAI SCH MED, NEW YORK, NY 10029 USA

[2] ROCKEFELLER UNIV, NEW YORK, NY 10021 USA

来源：

JOURNAL OF GENERAL VIROLOGY | 1976年 / 33卷 / OCT期

关键词：

D O I：

10.1099/0022-1317-33-1-159

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The neuraminidase inhibitor FANA inhibits the multicycle replication of influenza viruses in [bovine kidney MDBK] tissue culture. Influenza virus grown in the presence of FANA contains neuraminic acid on its envelope which then serves as receptor for other virus particles causing extensive aggregation. FANA inhibits influenza virus replication by preventing the enzymatic removal of neuraminic acid from the virus envelope.

引用

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页码：159 / 163

页数：5

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