LINEAR FREE-ENERGY RELATIONSHIP BETWEEN PARTITION COEFFICIENTS AND BINDING AND CONFORMATIONAL PERTURBATION OF MACROMOLECULES BY SMALL ORGANIC COMPOUNDS

被引:177
作者
HELMER, F
KIEHS, K
HANSCH, C
机构
关键词
D O I
10.1021/bi00848a023
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
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页码:2858 / &
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共 22 条
[1]  
ARIENS EJ, 1964, MOL PHARMACOL, V1, P29
[2]  
BRID AE, 1967, BIOCHEM PHARMACOL, V16, P2275
[3]   NEW SUBSTITUENT CONSTANT PI DERIVED FROM PARTITION COEFFICIENTS [J].
FUJITA, T ;
HANSCH, C ;
IWASA, J .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (23) :5175-&
[4]  
GOLDSTEIN A, 1949, PHARMACOL REV, V1, P102
[5]   RELATIONSHIP OF STRUCTURE TO EFFECTIVENESS OF DENATURING AGENTS FOR PROTEINS [J].
GORDON, JA ;
JENCKS, WP .
BIOCHEMISTRY, 1963, 2 (01) :47-+
[6]  
HANSCH C, 1965, MOL PHARMACOL, V1, P205
[7]   RHO-SIGMA-PI ANALYSIS . METHOD FOR CORRELATION OF BIOLOGICAL ACTIVITY + CHEMICAL STRUCTURE [J].
HANSCH, C ;
FUJITA, T .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (08) :1616-&
[8]   EFFECT OF INTRAMOLECULAR HYDROPHOBIC BONDING ON PARTITION COEFFICIENTS [J].
HANSCH, C ;
ANDERSON, SM .
JOURNAL OF ORGANIC CHEMISTRY, 1967, 32 (08) :2583-&
[9]   PARABOLIC DEPENDENCE OF DRUG ACTION UPON LIPOPHILIC CHARACTER AS REVEALED BY A STUDY OF HYPNOTICS [J].
HANSCH, C ;
STEWARD, AR ;
ANDERSON, SM ;
BENTLEY, D .
JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (01) :1-&
[10]   ROLE OF SUBSTITUENTS IN HYDROPHOBIC BONDING OF PHENOLS BY SERUM AND MITOCHONDRIAL PROTEINS [J].
HANSCH, C ;
KIEHS, K ;
LAWRENCE, GL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1965, 87 (24) :5770-&