SYNTHESIS OF 4-SUBSTITUTED PYRIMIDINE 2',3'-DIDEOXYNUCLEOSIDES

被引：15

作者：

DENAPOLI, L

MESSERE, A

MONTESARCHIO, D

PICCIALLI, G

SANTACROCE, C ^{[1
]}

机构：

[1] UNIV NAPLES,DIPARTIMENTO CHIM ORGAN & BIOL,VIA MEZZOCANNONE 16,I-80134 NAPLES,ITALY

[2] CNR,IST BIOCHIM PROT & ENZIMOL,I-80100 NAPLES,ITALY

来源：

NUCLEOSIDES & NUCLEOTIDES | 1991年 / 10卷 / 08期

关键词：

D O I：

10.1080/15257779108043057

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reaction of 5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-deoxythy-midine with triphenylphosphine/carbon tetrachloride, followed by deprotection of the 5'-hydroxyl group, afforded the 4-chloro derivative 3 from which some 4-substituted pyrimidin-2(1H)one-2',3'-dideoxyribosides were obtained by nucleophilic substitution under very mild conditions.

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页码：1719 / 1728

页数：10

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