EVIDENCE THAT HUMAN ORAL EPITHELIUM RECONSTITUTED INVITRO AND TRANSPLANTED ONTO PATIENTS WITH DEFECTS IN THE ORAL-MUCOSA RETAINS PROPERTIES OF THE ORIGINAL DONOR SITE

被引:117
作者
DELUCA, M
ALBANESE, E
MEGNA, M
CANCEDDA, R
MANGIANTE, PE
CADONI, A
FRANZI, AT
机构
[1] FREE UNIV BERLIN, IST ONCOL CLIN & SPERIMENTALE, W-1000 BERLIN 19, GERMANY
[2] FREE UNIV BERLIN, CATTEDRA CHIRURG SPECIALE ODONTOSTOMATOL, W-1000 BERLIN 19, GERMANY
[3] FREE UNIV BERLIN, IST ANAT UMANA NORMALE, W-1000 BERLIN 19, GERMANY
关键词
D O I
10.1097/00007890-199009000-00019
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Normal human skin-derived keratinocytes cultured in vitro reconstitute a stratified epidermis suitable for grafting onto burn patients and patients with skin defects such as giant nevi or chronic leg ulcers. In vitro experiments and long-term studies of patients receiving cultured epidermis autografts on muscular fascia suggest that skin keratinocytes possess an intrinsic site specific differentiation program that is fully expressed only when the reconstituted epidermis is transplanted in vivo to different body sites. In this study we cultivated for the first time palate-derived epithelial cells that were able to reconstitute a palatal epithelium. We also demonstrate that this epithelium can be successfully transplanted onto patients presenting lack of adherent keratinizing gingival mucosa and is able, in a relatively short time, to fully express the differentiation program typical of the original donor site. The possibility of obtaining large quantities of cultured epithelium, able to retain properties of the original donor site, starting from 1-3-mm2biopsies, could prove extremely useful in the reconstructive surgery of the mouth and of other mucosal body areas. © 1990 by Williams and Wilkins.
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页码:454 / 459
页数:6
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