TRANSIENT CEREBRAL ISCHEMIA AND BRAIN PROSTAGLANDINS

被引：189

作者：

GAUDET, RJ

LEVINE, L

机构：

[1] Department of Biochemistry, Brandeis University Waltham

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 86卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0006-291X(79)91796-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prostaglandin levels were measured in gerbil brain during cerebral ischemia for up to 2 hours, and during reperfusion after various periods of transient ischemia. The levels of PGF2α and its metabolite (13,14-dihydro-15-keto-PGF2α) were low and did not change during ischemia. However, PGF2α, 13,14-dihydro-15-keto-PGF2α, PGE2, and thromboxane B2 increased during reperfusion after brief episodes of ischemia. Indomethacin or aspirin inhibited this increase. Animals pretreated with indomethacin recovered more rapidly and were more active during reperfusion than those without treatment. © 1979.

引用

页码：893 / 901

页数：9

共 27 条

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